Respiratory infections, bacterial resistance and therapy with β-lactam antibiotics
نویسندگان
چکیده
منابع مشابه
β-Lactam Antibiotics Renaissance.
Since the 1940s β-lactam antibiotics have been used to treat bacterial infections. However, emergence and dissemination of β-lactam resistance has reached the point where many marketed β-lactams no longer are clinically effective. The increasing prevalence of multidrug-resistant bacteria and the progressive withdrawal of pharmaceutical companies from antibiotic research have evoked a strong rea...
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Background Trimethoprim-sulfamethoxazole (TMP-SMX) is a broad spectrum antimicrobial agent and also reduces the mortality among adults and children when used as prophylaxis against opportunistic infections in HIV infected patients. Drug resistant to TMP-SMX along with Extended spectrum b-lactamase (ESBL) production among Enterobacteriaceae is creating major therapeutic problem in clinical setti...
متن کاملDegradation of β-lactam antibiotics
Recent developments in the chemistry and biology of βlactam antibiotics which culminated with the introduction of several clinically useful classical and nonclassical β-lactams have been most thrilling and highly rewarding. While this review touches upon the historical development of β-lactams and their reactivity in a nutshell, it provides an overview of various aspects of chemical and enzymat...
متن کاملSkin testing with β-lactam antibiotics for diagnosis of β-lactam hypersensitivity in children.
OBJECTIVE Skin testing with penicilloyl-polylysine (PPL) and a minor determinant mixture (MDM) were previously recommended for evaluating β-lactam hypersensitivity. However, PPL and MDM have not been commercially available. This study was to determine the negative predictive value (NPV) of skin testing with β-lactam antibiotics for the diagnosis of β-lactam hypersensitivity. METHOD Patients a...
متن کاملOccupational allergy to β-lactam antibiotics
Background Contact urticaria in atopic patients was described by Hannuksela [1], among others, in 1980. It generally appears within 30 min of allergen contact and, in the majority of cases, is restricted to the areas of contact; however, local spread and generalized urticaria in the sense of anaphylaxis are seen. Allergic rhinoconjunctivitis and asthma may also subsequently occur [2]. Von Krogh...
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ژورنال
عنوان ژورنال: Heart - Lung (Varna)
سال: 2011
ISSN: 1310-6341
DOI: 10.14748/hl.v17i3-4.4324